Marijuana with Other Drugs

As with any medication, marijuana may interact with other drugs you are taking. In some cases, these reactions may be severe. Use medical marijuana cautiously, and call your doctor or the poison center if you have any of the following symptoms when using the drugs below.


Possible Side Effect

Disulfiram (Antabuse) or Fluoxetine (Prozac and Sarafem) Mild manic episodes, especially in those who are bipolar
Theophylline (Theo-24, Theo-Dur) Decreased amount of theophylline in the body
Amphetamines/Cocaine/Other stimulants Increased heart rate and blood pressure
Antihistamines (Allergy medications) Increased heart rate and/or drowsiness
Tricyclic antidepressants (Elavil, Pamelor) Increased heart rate, blood pressure and drowsiness
Alcohol (ethanol), Other sedatives Increased drowsy effects of both medications
Barbiturates (Nembutal, Butisol) Decreased metabolism of these drugs

*Side Effects and Drug Interactions were noted in studies that included marijuana, Dronabinol and Nabilone. Dronabinol and Nabilone are Food and Drug Administration-approved medicines derived from tetrahydrocannabinol (THC), a main component of marijuana.