If you have any questions about the following information, please contact the Poison and Drug Information Center at: 1-800-222-1222
As with any medication, marijuana may interact with other drugs you are taking. This can change how well your medication works or increase in your risk of side effects from your medication or marijuana
In some cases, these reactions may be severe
Below is a list of medications that could possibly interact with marijuana. This is NOT a complete list. If you have questions about interactions between marijuana and your medications, talk to your doctor or provider or call the Poison and Drug Information Center at 1-800-222-1222.
If you are a healthcare professional and would like to read more about drug interactions and kinetics, please visit our Healthcare Professionals section and view the Scientific Journal Articles.
| Generic Name | Brand Name | Possible Interaction | Possible Outcome |
|---|---|---|---|
| Alprazolam | Xanax | Additive Effects | Additional drowsiness |
| Amitriptyline | Elavil | Increased Medication Concentration | Increased Medication Side Effects |
| Amlodipine | Norvasc | Increased Marijuana Concentration | Increased Marijuana Side Effects |
| Apixaban | Eliquis | Increased Medication Concentration | Increased Medication Side Effects |
| Aripiprazole | Abilify | Increased Medication Concentration | Increased Medication Side Effects |
| Atorvastatin | Lipitor | Increased Medication Concentration | Increased Medication Side Effects |
| Buspirone Hydrochloride | Buspar | Increased Medication Concentration | Increased Medication Side Effects |
| Carvedilol | Coreg | Increased Medication Concentration | Increased Medication Side Effects |
| Celecoxib | Celebrex | Increased Medication Concentration | Increased Medication Side Effects |
| Clonazepam | Klonopin | Increased Medication Concentration | Increased Medication Side Effects |
| Clopidogrel Bisulfate | Plavix | Increased Medication Concentration | Increased Medication Side Effects |
| Cyclobenzaprine | Amrix | Decreased Drug Concentration (Smoking Marijuana) | Drug is less effective |
| Desogestrel; Ethinyl Estradiol | Reclipsen, Desogen, Kariva (others) | Increased Medication Concentration | Increased Medication Side Effects |
| Diazepam | Valium | Increased Medication Concentration | Increased Medication Side Effects |
| Diclofenac | Increased Medication Concentration | Increased Medication Side Effects | |
| Diltiazem Hydrochloride | Cartia, Tiazac | Increased Marijuana Concentration | Increased Marijuana Side Effectss |
| Donepezil Hydrochloride | Aricept | Increased Medication Concentration | Increased Medication Side Effects |
| Doxazosin Mesylate | Cardura | Increased Medication Concentration | Increased Medication Side Effects |
| Doxycycline | Increased Marijuana Concentration | Increased Marijuana Side Effectss | |
| Drospirenone; Ethinyl Estradiol | Yaz, Ocella, (others) | Increased Medication Concentration | Increased Medication Side Effects |
| Enalapril Maleate | Vasotec | Increased Marijuana Concentration | Increased Marijuana Side Effectss |
| Escitalopram Oxalate | Lexapro | Increased Marijuana Concentration | Increased Marijuana Side Effectss |
| Estradiol | Estrace, Natazia (others) | Increased Medication Concentration | Increased Medication Side Effects |
| Ethinyl Estradiol; Norgestimate | Ortho-Cyclen, Ortho Tri-Cyclen (others) | Increased Medication Concentration | Increased Medication Side Effects |
| Fenofibrate | Fibricor, Trilipix (others) | Increased Marijuana Concentration | Increased Marijuana Side Effectss |
| Finasteride | Propecia | Increased Medication Concentration | Increased Medication Side Effects |
| Fluconazole | Diflucan | Increased Marijuana Concentration | Increased Marijuana Side Effectss |
| Fluoxetine Hydrochloride | Prozac | Increased Marijuana Concentration | Increased Marijuana Side Effectss |
| Guanfacine | Intuniv | Increased Medication Concentration | Increased Medication Side Effects |
| Hydrocodone/APAP | Vicodin | Additive Effects | Increased Drowsiness and Sedation |
| Ibuprofen | Advil, Motrin | Increased Medication Concentration | Increased Medication Side Effects |
| Ketoconazole | Increased Marijuana Concentration | Increased Marijuana Side Effectss | |
| Lamotrigine | Lamictal | Increased Marijuana Concentration | Increased Marijuana Side Effectss |
| Loratadine | Claritin | Increased Medication Concentration | Increased Medication Side Effects |
| Lorazepam | Ativan | Increased Medication Concentration | Increased Medication Side Effects |
| Losartan Potassium | Cozaar | Increased Medication Concentration | Increased Medication Side Effects |
| Methylprednisolone | Medrol | Increased Medication Concentration | Increased Medication Side Effects |
| Montelukast | Singulair | Increased Medication Concentration | Increased Medication Side Effects |
| Morphine | MS Contin | Additive Effects | Increased Drowsiness and Sedation |
| Naproxen | Aleve, Naprosyn | Increased Medication Concentration | Increased Medication Side Effects |
| Ondansetron | Zofran | Increased Medication Concentration | Increased Medication Side Effects |
| Oxybutynin | Ditropan | Increased Medication Concentration | Increased Medication Side Effects |
| Oxycodone | Oxycontin | Additive Effects | Increased Drowsiness and Sedation |
| Quetiapine Fumarate | Seroquel | Increased Medication Concentration | Increased Medication Side Effects |
| Rivaroxaban | Xarelto | Increased Medication Concentration | Increased Medication Side Effects |
| Rosuvastatin | Crestor | Increased Medication Concentration | Increased Medication Side Effects |
| Simvastatin | Zocor | Increased Medication Concentration | Increased Medication Side Effects |
| Sitagliptin Phosphate | Januvia | Increased Medication Concentration | Increased Medication Side Effects |
| Tamsulosin Hydrochloride | Flomax | Increased Medication Concentration | Increased Medication Side Effects |
| Trazodone Hydrochloride | Desyrel | Increased Medication Concentration | Increased Medication Side Effects |
| Valacyclovir | Valtrex | Increased Medication Concentration | Increased Medication Side Effects |
| Valsartan | Diovan | Increased Medication Concentration | Increased Medication Side Effects |
| Verapamil Hydrochloride | Calan, Verelan (others) | Increased Medication Concentration | Increased Medication Side Effects |
| Warfarin | Coumadin | Increased Medication Concentration | Increased Risk Of Bleeding |
*Side Effects and Drug Interactions were noted in studies that included marijuana, Dronabinol and Nabilone. Dronabinol and Nabilone are Food and Drug Administration-approved medicines derived from tetrahydrocannabinol (THC), a main component of marijuana.
*Additive Effects mean the effect of two substances used together is greater than using either substance alone