Marijuana with Other Drugs

As with any medication, marijuana may interact with other drugs you are taking.

In some cases, these reactions may be severe. Use medical marijuana cautiously, and call your doctor or the poison center if you have any of the following symptoms when using the drugs below.

This is NOT a complete list of interactions. If you have questions about interactions between marijuana and your medications, call the Poison and Drug Information Center at 1-800-222-1222.


Disulfiram (Antabuse) or Fluoxetine (Prozac and Sarafem)
Theophylline (Theo-24, Theo-Dur)
Amphetamines/Cocaine/Other stimulants
Antihistamines (Allergy medications)
Tricyclic antidepressants (Elavil, Pamelor)
Alcohol (ethanol), Other sedatives
Barbiturates (Nembutal, Butisol)


Possible Side Effect

Mild manic episode, especially in those who are bipolar
Decreased amount of theophylline in the body
Increased heart rate and blood pressure
Increased heart rate and/or drowsiness
Increased heart rate, blood pressure and drowsiness
Increased drowsy effects of both medications
Decreased metabolism of these drugs 



*Side Effects and Drug Interactions were noted in studies that included marijuana, Dronabinol and Nabilone. Dronabinol and Nabilone are Food and Drug Administration-approved medicines derived from tetrahydrocannabinol (THC), a main component of marijuana.